WHO_Diagnostic_Criteria_for_Polycythemia_Vera v.0.1.0

Hemoglobin >16.5 g/dL in men or >16.0 g/dL in women, or hematocrit >49% in men or >48% in women

Bone marrow biopsy showing age-adjusted hypercellularity with trilineage growth (panmyelosis), including prominent erythroid, granulocytic, and megakaryocytic proliferation, with pleomorphic, mature megakaryocytes (differences in size)

Presence of JAK2 V617F or JAK2 exon 12 mutation

Subnormal serum erythropoietin level

Evaluates recorded findings against the World Health Organization diagnostic criteria to determine if the criteria for Polycythemia Vera (PV) are met.

Kevin Arjona

kevin.arjona@cambio.se

To assess whether the combination of recorded major and minor criteria meets the threshold for diagnosing Polycythemia Vera according to the WHO guidelines.

To be used in patients with suspected PV to determine whether the overall WHO criteria for PV diagnosis are met or not met. Requires meeting EITHER: All three Major Criteria OR Two Major Criteria AND the Minor Criterion. The guideline outputs a determination of

Not used to provide the final diagnosis, only determines if the criteria are formally met based on the inputs. Clinical correlation is still required.

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016 May 19;127(20):2375-90. doi: 10.1182/blood-2016-01-643569. Epub 2016 Mar 15. PMID: 26980727; PMCID: PMC4874220.

openEHR-EHR-OBSERVATION.who_diagnostic_criteria_for_polycythemia_vera, openEHR-EHR-EVALUATION.who_diagnostic_criteria_for_polycythemia_vera_assessment

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