Sickle_Cell_RBC_Exchange_Volume_guideline v.0
The sickle Cell RBC Exchange Volume calculator is used to estimate the volume of donor RBCs needed for RBC exchange in patients with sickle cell disease.
To estimate the volume of donor RBCs needed for RBC exchange in patients with sickle cell disease., Sickle cell disease is associated with a number of complications, including pain crises, acute chest syndrome, and stroke. Automated RBC exchange is an effective therapeutic modality both in the acute treatment of severe sickle cell-related complications and in long-term maintenance. Calculating the volume of donor RBCs necessary to achieve an appropriate reduction in HbS% is useful when ordering blood for RBC exchange procedures.
for Patients with sickle cell disease complications requiring RBC exchange normal patient height range (cm): 152-213 normal Patient hematocrit(%) : 20-30 ("Normal" indicates likely normal ranges for sickle cell patients) normal Patient's initial HgbS (%): 20-100 (If exchange is required for acute complication and pre-exchange HgbS % is unknown, can presume 100% HgbS) normal Goal HgbS range (%): 1-30 normal Hematocrit of transfused RBCs range (%):55-85
Transfused blood for sickle cell patients should be antigen-negative for any patient RBC alloantibodies, crossmatch compatible, and sickle negative. Note: device manufacturers may provide separate calculations for automated exchange. *ADVICE The calculated volume of replacement RBCs may be divided by 350 mL to approximate the number of RBC units to order. Adjustments to the patient’s hematocrit may require alterations to these calculations.
Brecher, Mark E; Shaz, Beth; Schwartz, Joseph, Look this up, too! A quick reference in Apheresis. 3rd edition. Bethesda, Maryland: AABB Press, 2013.
openEHR-EHR-OBSERVATION.basic_demographic, openEHR-EHR-OBSERVATION.height, openEHR-EHR-OBSERVATION.body_weight, openEHR-EHR-OBSERVATION.sickle_cell_rbc_exchange_volume_parameters
