SCORE2 (Systematic Coronary Risk Evaluation 2) is an advanced cardiovascular risk prediction algorithm developed to estimate the 10-year probability of both fatal and non-fatal cardiovascular disease (CVD) events. It is specifically designed for use in individuals aged 40 to 69 years who do not have pre-existing cardiovascular conditions or diabetes. The algorithm evaluates risk based on a combination of modifiable and non-modifiable factors, including age, sex, smoking status, systolic blood pressure, total cholesterol and HDL cholesterol. By integrating these variables, SCORE2 provides a personalized risk assessment that can guide preventive strategies, such as lifestyle modifications or pharmacological interventions.One of the key strengths of SCORE2 is its ability to support clinical decision-making by stratifying patients into different risk categories, helping healthcare professionals identify individuals who may benefit from early intervention. Interpretation Low-to-Moderate Cardiovascular Risk: - Risk <2.5% for individuals aged <50 years - Risk <5% for individuals aged 50–69 years Recommendation: Risk factor treatment is generally not recommended. High Cardiovascular Risk: - Risk between 2.5% and <7.5% for ages <50 years - Risk between 5% and <10% for ages 50–69 years Recommendation: Risk factor treatment should be considered. Very High Cardiovascular Risk: - Risk ≥7.5% for ages <50 years - Risk ≥10% for ages 50–69 years Recommendation: Risk factor treatment is generally recommended.