DLCO v.1

Diffusing capacity of the Lungs for Carbon Monoxide (DLCO) calculator corrects the pulmonary result for haemoglobin in patients with anemia.

Emma Malm

emma.malm@cambio.se

@ Cambio CDS

To calculate the corrected DLCO.

Use to correct the result from the DLCO pulmonary test with the patient haemoglobin based on gender and age. The following formula is used: DLCO Corrected = Predicted DLCO * (1.7 * Hgb / (Age & Sex-Factor + Hgb)), where Age & Sex-Factor is 9.38 for females and children <15 years and 10.22 for males >= 15 years.

Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Gustafsson P, Hankinson J, Jensen R, McKay R, Miller MR, Navajas D, Pedersen OF, Pellegrino R, Wanger J. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J. 2005 Oct;26(4):720-35. doi: 10.1183/09031936.05.00034905. PMID: 16204605. Marrades RM, Diaz O, Roca J, Campistol JM, Torregrosa JV, Barberà JA, Cobos A, Félez MA, Rodriguez-Roisin R. Adjustment of DLCO for hemoglobin concentration. Am J Respir Crit Care Med. 1997 Jan;155(1):236-41. doi: 10.1164/ajrccm.155.1.9001318. PMID: 9001318. Rosenberg E. The 1995 update of recommendations for a standard technique for measuring the single-breath carbon monoxide diffusing capacity (transfer factor). Am J Respir Crit Care Med. 1996 Jul;154(1):265-6. doi: 10.1164/ajrccm.154.1.8680694. Corrected and republished in: Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):827-8. PMID: 8680694. Hughes JM, Bates DV. Historical review: the carbon monoxide diffusing capacity (DLCO) and its membrane (DM) and red cell (Theta.Vc) components. Respir Physiol Neurobiol. 2003 Nov 14;138(2-3):115-42. doi: 10.1016/j.resp.2003.08.004. PMID: 14609505.

openEHR-EHR-OBSERVATION.basic_demographic, openEHR-EHR-OBSERVATION.lab_test-full_blood_count, openEHR-EHR-OBSERVATION.dlco